Development and cellular localization of rat testicular aromatase activity

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چکیده

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Development and cellular localization of rat testicular aromatase activity.

Oestradiol secretion by isolated Leydig cells, Sertoli cells, myoid cells, germinal cells and liver cells from rats of different ages was measured by a validated radioimmunoassay technique. All cells, except germinal cells and liver cells, produced oestradiol when incubated in the presence of testosterone. Sertoli cells from 7- and 10-day-old rats and from prenatally irradiated adult rats were ...

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Rat testicular germ cells and epididymal sperm contain active P450 aromatase.

Although testosterone is the principal sex steroid produced by the testis, estrogen is known to be produced by both Leydig and Sertoli cells during different developmental periods. Additionally, evidence is unfolding to suggest that germ cells might also participate in the synthesis of estrogen within the male reproductive tract. We have recently reported that the messenger ribonucleic acid (mR...

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ژورنال

عنوان ژورنال: Reproduction

سال: 1982

ISSN: 1470-1626,1741-7899

DOI: 10.1530/jrf.0.0650281